Gradient compatibility

The Corona CAD detector
is fully compatible with gradient operation. Volatile mobile phases such as those used with MS are appropriate for use with the Corona CAD.The figure shows a five minute linear gradient from 10mM ammonium acetate/2% IPA in H20 to 10mM ammonium acetate in 75% ACN/25% MeOH. In the example, note the increased nebulization efficiency with increased organic solvent observed during a reversed phase gradient.

Complementary and orthogonal data

How confident are you that UV and MS are
showing all the compounds in your sample?

The Corona CAD’s unique method of
detection produces data complementary to
that of UV and mass spectrometry.
When three detectors analyzed the same
sample, all responded based on distinctly different physicochemical properties, providing truly orthogonal data. MS only detected two of the three species. With the Corona CAD, three peaks with similar responses were observed – you not only see what you know is in your sample, but what is actually there.