CAD technology consistently provides
high sensitivity and low limits of detection
for a wide range of analytes, irrespective
of their chemical structure. The Corona CAD can readily detect compounds present in low nanogram quantities. For example, 10 nanograms each of 4 carbohydrates are easily detected in the example shown.

Challenging to quantitate

Trace impurities can be difficult to assess.
Often impurities (e.g. degradants, trace
residues) have no chromophore and are not detectable with UV. To accurately measure trace impurity levels, high sensitivity and a wide dynamic range are required. With sensitivity to low nanograms and over 4 orders of magnitude dynamic range, the Corona CAD is ideal for trace impurity detection or cleaning validation approaches. Detection of impurities of 0.005% along with the parent compound are routinely achieved.