Relative strengths of universal detection technologies
Charged Aerosol Detection (CAD) delivers outstanding performance in all of the important criteria necessary for a universal detector. In contrast, each of the other detection technologies has significant weaknesses in its performance, limiting its usefulness as a universal HPLC detector. CAD overcomes the shortcomings of other detection methods in a single platform. None of the other detection methods are able to match the overall performance of Charged Aerosol Detection.

CAD represents a significant new universal detection option for HPLC that not only exceeds the capabilities of current options, but can push the boundaries of universal detection into areas where current methods are not able to perform. Utilization of CAD can both increase the efficiency of existing analytical operations, and open up entirely new possibilities for bioanalytical chemistry in the future.

What makes the Corona detector unique –
charged aerosol technology.

CAD® (Charged Aerosol Detection) is a unique technology, in which the HPLC column eluent is first nebulized with nitrogen and the droplets are dried to remove mobile phase, producing analyte particles.
     A secondary stream of nitrogen becomes positively charged as it passes a high-voltage, platinum corona wire. This charge transfers to the opposing stream of analyte particles.
     The charge is transferred to a collector where it is measured by a highly sensitive electrometer, generating a signal in direct proportion to the quantity of analyte present.

Ideal for a wide range
of applications.

Corona Charged Aerosol Detection is applicable for virtually any non- or semi-volatile compound, including:

• Drug compounds
• Drug scaffolds
• Carbohydrates
• Lipids
• Steroids
• Peptides
• Proteins
• Polymers

In industries such as:

• Pharmaceutical
• Foods
• Consumer products
• Industrial chemicals
• Life science research

Superior performance – in more ways than one.

	Sensitivity	Dynamic Range	Consistency of Response	Applicability	Reproducibility	Chromatographic Compatibility	Ease of Use
Charged Aerosol
UV
Evaporative Light Scattering
Chemiluminescence Nitrogen
Refractive Index